Anle138b-F105

Anle138b-F105 is an autophagy targeting chimera (AUTOTAC) with DC50 values of 3 nM. Anle138b-F105 targetes tauP301L for lysosomal degradation[1].

Product Specifications

CAS Number

[2941386-44-1]

UNSPSC

12352005

Target

Autophagy; AUTOTACs

Type

Reference compound

Related Pathways

Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anle138b-f105.html

Purity

98.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(C=C1)=CC=C1COC2=CC=CC(CNCCOCCOCCNC3=CC(C4=CC(C5=CC=C(OCO6)C6=C5)=NN4)=CC=C3)=C2

Molecular Formula

C36H37FN4O5

Molecular Weight

624.70

References & Citations

[1]Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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