Midaglizole

Midaglizole ((±) -DG5128 free base; DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo[1][2][3].

Product Specifications

CAS Number

[66529-17-7]

Product Name Alternative

(±) -DG5128 (free base) ; DG5128 (free base)

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/midaglizole.html

Purity

98.28

Solubility

DMSO : 162.5 mg/mL (ultrasonic)

Smiles

C1(C(C2=CC=CC=C2)CC3=NCCN3)=NC=CC=C1

Molecular Formula

C16H17N3

Molecular Weight

251.33

References & Citations

[1]Hirohashi M, et al. Intrinsic pressor activity of midaglizole, an alpha-2 adrenoceptor antagonist, in pithed rats. Jpn J Pharmacol. 1990 Aug;53 (4) :519-20. |[2]Ohneda K, et al. Mechanism of insulin secretion by midaglizole. Diabetes Res Clin Pract. 1993 Feb;19 (2) :127-32.|[3]Proks P, et al. Inhibition of recombinant K (ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382. Eur J Pharmacol. 2002 Sep 27;452 (1) :11-9.