NSC319726

NSC319726 (ZMC1) is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM) ; shows no inhibition for p53 wild-type cells.

Product Specifications

CAS Number

[71555-25-4]

Product Name Alternative

ZMC1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NSC319726.html

Purity

99.60

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

C/C(C1=NC=CC=C1)=N\NC(N2CCC2)=S

Molecular Formula

C11H14N4S

Molecular Weight

234.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Yu X, et al. Allele-specific p53 mutant reactivation. Cancer Cell. 2012 May 15;21 (5) :614-25.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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