2-Deoxy-D-glucose-d1

2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

Product Specifications

CAS Number

[188004-07-1]

Product Name Alternative

2-DG-d1; 2-Deoxy-D-arabino-hexose-d1; D-Arabino-2-deoxyhexose-d1

UNSPSC

12352211

Target

Apoptosis; Hexokinase; HSV; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Others

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

98.0

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O=C([2H])C[C@@H](O)[C@H](O)[C@H](O)CO

Molecular Formula

C6H11DO5

Molecular Weight

165.16

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Zhu Z, et al. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005 Aug 1;65 (15) :7023-30.; Ueyama A, et al. Nonradioisotope assay of glucose uptake activity in r