Recombinant Human GDF15 Protein (Sumo Tag)

Product Specifications

Background

Growth/differentiation factors (GDF-1 to GDF-15) are members of the BMP family of TGF-beta superfamily proteins. They are produced as inactive preproproteins which are then cleaved and assembled into active secreted homodimers. GDF dimers are disulfide-linked with the exception of GDF-3 and-9. GDF proteins are important during embryonic development, particularly in the skeletal, nervous, and muscular systems.

Abbreviation

GDF15

Synonyms

Growth/differentiation factor 15; MIC-1; NAG-1; PDF; PLAB

UniProt

Q99988

Accession Number

Q99988

Expression System

E.coli

Tag

N-Sumo

Sequence

Ala197-Ile308

Field of Research

Cancer; Metabolism; Cardiovascular; Developmental Biology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.