Recombinant Rat IL-6 Protein
Product Specifications
Background
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
Abbreviation
IL-6
Synonyms
BSF; IFNB; BSF2; CDF; HGF; HSF; IFNB2; Interleukin-6; Il6; Il 6; Interleukin 6; Il-6
UniProt
P20607
Accession Number
P20607
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-Thr211
Field of Research
Cancer; Cardiovascular; Immunology
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
24 kDa
Observed Molecular Weight
25-33 kDa
Species
Rat
Available Sizes
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