Recombinant Human Neurotensin/NT protein (His tag)
Product Specifications
Background
DPEP2 (MBD-2) belongs to the membrane-bound dipeptidase family. There are three members of this family as membrane-bound dipeptidase-1 (MBD-1), membrane-bound dipeptidase-2 (MBD-2) and membrane-bound dipeptidase-3 (MBD-3) .MBD-2 is expressed at highest levels in lung, heart, and testis and at some what lower levels in spleen.MBD-2 is membrane-bound through a glycosylphosphatidyl-inositol linkage and probably is a metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) .It is generally recognized that rapid cleavage of LTD4 is important in inactivating the broncho-and vaso-constrictive effects of cysteinyl LTs in asthmatic and inflammatory processes.
Abbreviation
Neurotensin; NT
Synonyms
NTS; Neurotensin/neuromedin N
UniProt
P30990
Accession Number
P30990
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-Leu148
Field of Research
Signal Transduction; Neuroscience; metabolism
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
16.2 kDa
Observed Molecular Weight
35 kDa
Species
Human
Available Sizes
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