Recombinant Human IGFBP3 protein (His tag)
Product Specifications
Background
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity.Promotes testicular germ cell apoptosis.
Abbreviation
IGFBP3
Synonyms
IBP-3; IGF-binding protein 3; IGFBP-3
UniProt
P17936
Accession Number
P17936
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-Lys291
Field of Research
Cell Biology, Signal Transduction, Cardiovascular, Metabolism, Cancer
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 80% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
32.5 kDa
Observed Molecular Weight
38-42 kDa
Species
Human
Available Sizes
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