Recombinant Rabbit TNF-α protein (His tag)
Product Specifications
Background
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1, p55R) and TNF-R2 (TNF receptor type 2, p75R) . TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells.
Abbreviation
TNF-α
Synonyms
Cachectin; TNF; TNF-Alpha; TNF-a; TNFA; TNFSF2; Tumor Necrosis Factor
UniProt
P04924
Accession Number
P04924
Expression System
E.coli
Tag
N-His
Sequence
Leu 80-Leu 235
Field of Research
Immunology; Signal Transduction; Microbiology; Cancer; Cardiovascular
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
17.1 kDa
Observed Molecular Weight
18 kDa
Species
Rabbit
Available Sizes
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