Recombinant Mouse TGFBR2 protein (His tag)
Product Specifications
Background
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinity cell surface receptors: TGF-β receptor type I (TGF-β-RI), TGF-β receptor type II (TGF-β-RII), and TGF-ββ receptor type III (TGF-β-RIII) . TGF-β RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF-β) receptor subfamily. TGF-β RII has a protein kinase domain which can form a heterodimeric complex with another receptor protein and bind TGF-beta. This receptor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
Abbreviation
TGFBR2
Synonyms
TGF-beta receptor type II; TGF-beta receptor type-2; TGF-beta type II receptor; TGFR-2; TbetaR-II; Tgfbr2; Transforming Growth Factor-Beta Receptor Type II; Transforming growth factor-beta receptor type II
UniProt
Q62312
Accession Number
Q62312
Expression System
E.coli
Tag
N-His
Sequence
Asp 371-Lys 592
Field of Research
Cardiovascular; Signal Transduction; Stem Cells; Cancer; Metabolism; Neuroscience
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/ht1odh
Product MSDS
https://789.bio/eb/PCVSt5
Calculated Molecular Weight
24.3 kDa
Observed Molecular Weight
32 kDa
Species
Mouse
Available Sizes
Curated Selection
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