Recombinant Mouse ABL1/c-Abl protein (His tag)
Product Specifications
Background
Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Abbreviation
ABL1; c-Abl
Synonyms
ABL 1; Abelson tyrosine protein kinase 1; JTK7; Proto-oncogene c-Abl; bcr/abl; p150; v abl
UniProt
P00520
Accession Number
P00520
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Asn 193
Field of Research
Signal Transduction; Cancer; Epigenetics and Nuclear Signaling; Neuroscience
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
21.1 kDa
Observed Molecular Weight
25 kDa
Species
Mouse
Available Sizes
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