Recombinant Mouse HP1α protein (His tag)
Product Specifications
Background
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) . Can interact with lamin-B receptor (LBR) . This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Abbreviation
HP1α
Synonyms
Antigen p25; CBX5; Chromobox 5; Epididymis luminal protein 25; HEL25; HP1 alpha; HP1A; Heterochromatin protein 1
UniProt
Q61686
Accession Number
Q61686
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Ser 191
Field of Research
Epigenetics and Nuclear Signaling; Tags & Cell Markers
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
20.9 kDa
Observed Molecular Weight
25 kDa
Species
Mouse
Available Sizes
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