Recombinant Mouse Chromogranin-A/Chga protein (His Tag)
Product Specifications
Background
Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation . Pyroglutaminated (pGlu) -serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress .
Abbreviation
Chromogranin-A; Chga
Synonyms
CHG A; CMGA; CgA; Chga; Chromogranin A; Chromogranin A parathyroid secretory protein 1; Chromogranin A precursor; ChromograninA; ER-37; Pancreastatin; Parastatin; Parathyroid secr; beta Granin; betagranin (N-terminal fragment of chromogranin A) ; catestatin; chromofungin
UniProt
P26339
Accession Number
P26339
Expression System
E.coli
Tag
N-His
Sequence
Leu19-Met150
Applications
Immunogen
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
14.4 KDa
Observed Molecular Weight
15-20 kDa
Species
Mouse
Available Sizes
Curated Selection
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