Recombinant Human PTCH1 protein (His tag)
Product Specifications
Background
Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH) . Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Abbreviation
PTCH1
Synonyms
PTC; PTC1; PTCH1; Protein patched homolog 1
UniProt
Q13635
Accession Number
Q13635
Expression System
E.coli
Tag
N-His
Sequence
Glu 122-Asp 436
Field of Research
Cancer; Cell Biology; Neuroscience; Stem Cells
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
34.5 kDa
Observed Molecular Weight
38 kDa
Species
Human
Available Sizes
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