Recombinant Human MEC/CCL28 protein (GST, His tag)
Product Specifications
Background
Chemokine (C-C Motif) Ligand 28 (CCL28) is a novel chemokine that shares the most homology with CCL27/CTACK. CCL28 shows chemotactic activity for resting CD4, CD8 T-cells and eosinophils. It Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. CCR10 (GPR2 orphan receptor) is also the receptor for CCL27/CTACK. CCL28 is preferentially expressed by epithelial cells of diverse tissues, with highest expression level in normal and pathological colon. It is also expressed in normal and asthmatic lung tissues. Human and mouse CCL28 shares 83% sequence identity in their mature regions.
Abbreviation
MEC; CCL28
Synonyms
C-C Motif Chemokine 28; CCL28; MEC; Mucosae-Associated Epithelial Chemokine; Protein CCK1; SCYA28; Small-Inducible Cytokine A28
UniProt
Q9NRJ3
Accession Number
Q9NRJ3
Expression System
E.coli
Tag
N-GST & C-His
Sequence
Ser 20-Tyr 127
Field of Research
Immunology; metabolism
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
36.8 kDa
Observed Molecular Weight
38 kDa
Species
Human
Available Sizes
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