Recombinant Human DRP1 protein (His tag)

Product Specifications

Background

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport.

Abbreviation

DRP1

Synonyms

DNM1L; Dnm1p/Vps1p-like protein (DVLP) ; Dynamin family member proline-rich carboxyl-terminal domain less (Dymple) ; Dynamin-1-like protein; Dynamin-like protein

UniProt

O00429

Accession Number

O00429

Expression System

E.coli

Tag

N-His

Sequence

Asn 448-Trp 736

Field of Research

Cancer; cell Biology; Metabolism; Neuroscience; signal Transduction

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.