Recombinant Human JNK1/MAPK8 Protein (His tag)
Product Specifications
Background
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Phosphorylates heat shock factor protein 4.
Abbreviation
JNK1; MAPK8
Synonyms
JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c
UniProt
P45983
Accession Number
P45983
Expression System
E.coli
Tag
N-His & C-His
Sequence
Met1-Glu350
Field of Research
Signal Transduction; Cancer; epigenetics and nuclear signal; immunology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/vqwaw5
Product MSDS
https://789.bio/eb/CKKly5
Calculated Molecular Weight
38.4 kDa
Observed Molecular Weight
38 kDa
Species
Human
Available Sizes
Curated Selection
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