Recombinant Human PAK6 protein (His tag)
Product Specifications
Background
As downstream targets of the Rho GTPases, the p21-activated kinase (PAK) family of serine/threonine kinases regulates the organization of the actin cytoskeleton in mammalian cells. The PAK family is structurally categorized in two groups, each with three members: group I PAK1-3, and group II PAK4-6. PAK6 is expressed most highly in brain and testes, with lower levels in multiple tissues. Both MKK6 and p38 MAPK activate PAK6, suggesting a role for this kinase in the cellular stress response.
Abbreviation
PAK6
Synonyms
PAK6; Serine/threonine-protein kinase PAK 6; p21-activated kinase 6 (PAK-6)
UniProt
Q9NQU5
Accession Number
Q9NQU5
Expression System
E.coli
Tag
N-His & C-His
Sequence
Met 1-Cys 681
Field of Research
Signal Transduction; Cancer; Cell Biology; Neuroscience
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
74.8 kDa
Observed Molecular Weight
80 kDa
Species
Human
Available Sizes
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