Recombinant Human PGD protein (His tag)
Product Specifications
Background
6-phosphogluconate dehydrogenase (PGD) is a cytoplasm-located protein, and belongs to the 6-phosphogluconate dehydrogenase family. 6PGD is the second dehydrogenase in the pentose phosphate shunt. It catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH. Mutations within the gene coding this enzyme result in 6-phosphogluconate dehydrogenase deficiency, an autosomal hereditary disease effecting the red blood cells.
Abbreviation
PGD
Synonyms
6-phosphogluconate dehydrogenase;6PGD; Decarboxylating; PGD; PGDH
UniProt
P52209
Accession Number
P52209
Expression System
E.coli
Tag
N-His & C-His
Sequence
Met 1-Ala 483
Field of Research
Signal Transduction; metabolism
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
53.0 kDa
Observed Molecular Weight
55 kDa
Species
Human
Available Sizes
Documents
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