Recombinant Human RAB38 protein (His tag)
Product Specifications
Background
May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes, the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity) . Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211) . Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991) . In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity) .
Abbreviation
RAB38
Synonyms
Melanoma antigen NY-MEL-1; RAB38; Ras-related protein Rab-38
UniProt
P57729
Accession Number
P57729
Expression System
E.coli
Tag
N-His & C-His
Sequence
Met 1-Ser 211
Field of Research
Signal Transduction
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
23.1 kDa
Observed Molecular Weight
29 kDa
Species
Human
Available Sizes
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