Coumaran

Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide.[2].

Product Specifications

CAS Number

[496-16-2]

Product Name Alternative

2,3-Dihydrobenzofuran

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cholinesterase (ChE) ; Endogenous Metabolite; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/coumaran.html

Purity

99.67

Solubility

DMSO : 150 mg/mL (ultrasonic) |H2O : 150 mg/mL (ultrasonic)

Smiles

C12=CC=CC=C1CCO2

Molecular Formula

C8H8O

Molecular Weight

120.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Yallappa Rajashekar, et al. Acetylcholinesterase Inhibition by Biofumigant (Coumaran) From Leaves of Lantana Camara in Stored Grain and Household Insect Pests. Biomed Res Int. 2014;2014:187019.|[2]de Castro Oliveira LG, et al. In Vitro Effects of the Neolignan 2,3-Dihydrobenzofuran Against Leishmania Amazonensis. Basic Clin Pharmacol Toxicol. 2017 Jan;120 (1) :52-58.