Recombinant Human SCO2 protein (His tag)
Product Specifications
Background
Acts as a copper chaperone, transporting copper to the Cu (A) site on the cytochrome c oxidase subunit II (COX2) .Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) . This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.
Abbreviation
SCO2
Synonyms
Protein SCO2 homolog; SCO2; mitochondrial
UniProt
O43819
Accession Number
O43819
Expression System
E.coli
Tag
N-His & C-His
Sequence
Gly 42-Ser 266
Field of Research
Metabolism; Signal Transduction; Tags and Cell Markers
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
24.6 kDa
Observed Molecular Weight
30 kDa
Species
Human
Available Sizes
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