Recombinant Human Zic3 protein (His tag)
Product Specifications
Background
ZIC3, or zic family member 3, is a molecule that regulates early embryonic patterning in vertebrates. ZIC3 has putative roles in a number of developmental signalling pathways that have distinct roles in establishing the left-right axis. In addition, ZIC3 is also considered as target of MiR-564, a tumor suppressor in human lung cancer. Variants in the ZIC3 gene are rare, but have demonstrated their profound clinical significance in X-linked heterotaxy, affecting in particular male patients with abnormal arrangement of thoracic and visceral organs.
Abbreviation
Zic3
Synonyms
ZIC3; Zinc finger protein 203; Zinc finger protein ZIC 3; Zinc finger protein of the cerebellum 3
UniProt
O60481
Accession Number
O60481
Expression System
E.coli
Tag
N-His & C-His
Sequence
Met 1-Val467
Field of Research
Developmental Biology; Epigenetics and Nuclear signalin; Stem Cells
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
51.3 kDa
Observed Molecular Weight
52 kDa
Species
Human
Available Sizes
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