Recombinant Human GABRβ3 (GABRB3) protein (His tag)
Product Specifications
Background
Γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC) . Alteration in the gene results in increased tactile sensitivity, or hypersensitivity.Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia.[1][3] GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P) .
Abbreviation
GABRβ3
Synonyms
GABA (A) receptor subunit beta-3; GABRB3; Gamma-aminobutyric acid receptor subunit beta-3
UniProt
P28472
Accession Number
P28472
Expression System
E.coli
Tag
N-His & C-His
Sequence
Ser 26-Tyr 245
Field of Research
Neuroscience
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
24.1 kDa
Observed Molecular Weight
32 kDa
Species
Human
Available Sizes
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