Recombinant Human GLUT6/SLC2A6 protein (GST, His tag)
Product Specifications
Background
GLUT6 as a functionally uncharacterized transporter that putatively works in inflammatory responses. Inflammatory stimuli increase GLUT6 expression level, although GLUT6-knockout mice exhibit a subtle phenotype to lipopolysaccharide administration. Metabolomics and in vitro analyses show that GLUT6 functions as a glycolysis modulator in inflammatory macrophages. GLUT6 does not mediate glucose uptake and is localized on lysosomal membranes. We conclude that GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates inflammatory responses by affecting the metabolic shift in macrophages.
Abbreviation
GLUT6; SLC2A6
Synonyms
GLUT6; Glucose transporter type 6; SLC2A6; Solute carrier family 2; facilitated glucose transporter member 6
UniProt
Q9UGQ3
Accession Number
Q9UGQ3-1
Expression System
E.coli
Tag
N-GST & C-His
Sequence
Asn 216-Thr 289
Field of Research
Metabolism; Signal Transduction
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/phaes0
Product MSDS
https://789.bio/eb/dq1OdP
Calculated Molecular Weight
33.0 kDa
Observed Molecular Weight
35 kDa
Species
Human
Available Sizes
Curated Selection
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