Recombinant Human PIK3R5 protein (His tag)
Product Specifications
Background
Phosphoinositide 3-kinase regulatory subunit 5 (PIK3R5, also PI3-kinase p101 subunit, Ptdlns-3-kinase p101, and p101-PI3K) is a 97 kDa regulatory subunit of the PI3K gamma complex. It is expressed as a heterodimer with the catalytic subunit PIK3CG/p120. Human PIK3R5 is 880 amino acids (aa) in length. The heterodimerization region is made up of aa 25-101, and aa 653-753 comprise the region for interaction with G beta gamma proteins. A second 55 kDa isoform is formed by the deletion of aa 1-386.
Abbreviation
PIK3R5
Synonyms
PIK3R5; PI3-kinase regulatory subunit 5; Phosphoinositide 3-kinase regulatory subunit 5
UniProt
Q8WYR1
Accession Number
Q8WYR1-2
Expression System
E.coli
Tag
N-His & C-His
Sequence
Met 1-Pro 494
Field of Research
Signal Transduction
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
54.2 kDa
Observed Molecular Weight
58 kDa
Species
Human
Available Sizes
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