Recombinant Human IL-28B/IFN-lambda-3 protein (His tag)
Product Specifications
Background
Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition, IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
Abbreviation
IL-28B; IFN-lambda-3
Synonyms
Cytokine Zcyto; ZCYTO; IFNL3; IFN-lambda-3; IFN-lambda-4; IL-28B; IL-28C; IL28B; IL28C; Cytokine Zcyto22; IFNL4; IFN-lambda 3; interferon lambda 3; Interferon Lambda-3; Interferon Lambda-4; Interleukin-28B; Interleukin-28C; ZCYTO22
UniProt
Q8IZI9
Accession Number
Q8IZI9
Expression System
E.coli
Tag
N-His
Sequence
Val 22-Val 196
Field of Research
Signal Transduction; Microbiology; immunology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
19.1 kDa
Observed Molecular Weight
25 kDa
Species
Human
Available Sizes
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