Recombinant Human TRAPPC8 protein (His tag)
Product Specifications
Background
The transport protein particle (TRAPP) complex was initially identified as a tethering factor for COPII vesicle. Subsequently, three forms (TRAPPI, II, and III) have been found and TRAPPIII has been reported to serve as a regulator in autophagy. This study investigates a new role of mammalian TRAPPIII in ciliogenesis. We found a ciliopathy protein, oral-facial-digital syndrome 1 (OFD1), interacting with the TRAPPIII-specific subunits TRAPPC8 and TRAPPC12. TRAPPC8 is necessary for the association of OFD1 with pericentriolar material 1 (PCM1) .
Abbreviation
TRAPPC8
Synonyms
KIAA1012; Protein TRS85 homolog; TRAPPC8; Trafficking protein particle complex subunit 8
UniProt
Q9Y2L5
Accession Number
Q9Y2L5-1
Expression System
E.coli
Tag
N-His & C-His
Sequence
Gly 100-Gln 250
Field of Research
Signal Transduction
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
16.5 kDa
Observed Molecular Weight
20 kDa
Species
Human
Available Sizes
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