Recombinant Human SQSTM1/ p62 protein (His tag)

Product Specifications

Background

Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity) . May be involved in cell differentiation, apoptosis, immune response and regulation of K (+) channels.

Abbreviation

SQSTM1; p62

Synonyms

A170; DMRV; EBI 3 associated protein p60; EBIAP; FTDALS3; ORCA; OSF-6; OSIL; P62b; PDB 3; PDB3; SQSTM 1; STAP; STONE14; Sequestosome 1; ZIP3; p60

UniProt

Q13501

Accession Number

Q13501

Expression System

E.coli

Tag

N-His

Sequence

Ser 3-Lys 102

Field of Research

Signal Transduction; Epigenetics and Nuclear Signaling; Cardiovascular; Cancer; Neuroscience

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.