Recombinant Human SQSTM1/ p62 protein (His tag)
Product Specifications
Background
Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity) . May be involved in cell differentiation, apoptosis, immune response and regulation of K (+) channels.
Abbreviation
SQSTM1; p62
Synonyms
A170; DMRV; EBI 3 associated protein p60; EBIAP; FTDALS3; ORCA; OSF-6; OSIL; P62b; PDB 3; PDB3; SQSTM 1; STAP; STONE14; Sequestosome 1; ZIP3; p60
UniProt
Q13501
Accession Number
Q13501
Expression System
E.coli
Tag
N-His
Sequence
Ser 3-Lys 102
Field of Research
Signal Transduction; Epigenetics and Nuclear Signaling; Cardiovascular; Cancer; Neuroscience
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
10.9 kDa
Observed Molecular Weight
15 kDa
Species
Human
Available Sizes
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