Recombinant Human VWFCP/ADAMTS13 protein (His tag)
Product Specifications
Background
Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.Zinc and calcium ions cooperatively modulate enzyme activity. The cleavage of the pro-domain is not required for protease activity. Dependence on calcium for proteolytic activity is mediated by the high affinity site.
Abbreviation
VWFCP; ADAMTS13
Synonyms
ADAM-TS 13; ADAMTS 13; ATS13; C9orf8; TTP; Von Willebrand factor cleaving protease; vWF CP; vWF-cleaving protease
UniProt
Q76LX8
Accession Number
Q76LX8
Expression System
E.coli
Tag
N-His
Sequence
Thr 1151-Thr 1427
Field of Research
Signal Transduction; Cancer; Cell Biology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
30.4 kDa
Observed Molecular Weight
31 kDa
Species
Human
Available Sizes
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