Recombinant Human RANTES protein (GST&His tag)
Product Specifications
Background
Human Chemokine (C-C Motif) Ligand 5 (CCL5) plays an active role in recruiting leukocytes into inflammatory sites. CCL5 is secreted by many cell types at inflammatory sites and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. N-Terminal truncated CCL5/RANTES, Met-RANTES, and amino-oxypentane (AOP) -RANTES exhibit antagonist or partial agonist functions on their receptors. CCL5/RANTES attracts different subtypes of leukocytes into inflamed tissue and intervenes in a wide range of allergic and autoimmune diseases.
Abbreviation
RANTES
Synonyms
C-C Motif Chemokine 5; CCL5; D17S136E; EoCP; Eosinophil Chemotactic Cytokine; SCYA5; SIS-Delta; Small-Inducible Cytokine A5; T Cell-Specific Protein P228; T-Cell-Specific Protein RANTES; TCP228
UniProt
P13501
Accession Number
P13501
Expression System
E.coli
Tag
N-GST & C-His
Sequence
Pro 25-Ser 91
Field of Research
Cardiovascular; immunology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
32.3 kDa
Observed Molecular Weight
42 kDa
Species
Human
Available Sizes
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