Recombinant Human BDNF protein (His tag)
Product Specifications
Background
The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
Abbreviation
BDNF
Synonyms
Abrineurin; BDNF; Brain-Derived Neurotrophic Factor
UniProt
P23560
Accession Number
P23560
Expression System
E.coli
Tag
N-His
Sequence
His 129-Arg 247
Field of Research
Cardiovascular; Neuroscience; metabolism
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/4kg0c4
Product MSDS
https://789.bio/eb/LCKxuS
Calculated Molecular Weight
13.0 kDa
Observed Molecular Weight
15 kDa
Species
Human
Available Sizes
Curated Selection
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