Recombinant Human IL1B protein (His tag)
Product Specifications
Background
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra) . In clinical, it has been reported that Interleukin (IL) -1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of successful pregnancy. Proinflammatory interleukin (IL) -1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc)
Abbreviation
IL1B
Synonyms
IL1F; IL-1F; pro IL1F; IL-1; IL1-BETA; IL1F2; IL1 beta; IL1B; catabolin; IL-1B; pro Catabolin; pro IL1B; pro IL1F2; pro leukocytic endogenous mediator; pro leukocytic pyrogen; pro lymphocyte activating factor; pro mononuclear cell factor; IL-1F2; IL 1B; IL-1 beta
UniProt
P01584
Accession Number
P01584
Expression System
E.coli
Tag
N-His
Sequence
Ala 117-Ser 269
Field of Research
Cardiovascular; immunology; metabolism
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/p0x5d5
Product MSDS
https://789.bio/eb/dHZamP
Calculated Molecular Weight
16.7 kDa
Observed Molecular Weight
18 kDa
Species
Human
Available Sizes
Curated Selection
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