Recombinant Human FGF23 protein (SUMO, His tag)

Product Specifications

Background

This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR) . Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC) .

Abbreviation

FGF23

Synonyms

ADHR; FGF-23; FGF23; Fgf23; HPDR2; HYPF; PHPTC; fibroblast growth factor 23; phosphatonin

UniProt

Q9GZV9

Accession Number

Q9GZV9

Expression System

E.coli

Tag

N-SUMO-His

Sequence

Ala 24-Val 126

Field of Research

Signal Transduction; Stem Cells; Cancer; Developmental Biology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.