Recombinant Human LL-37 protein (GST tag)
Product Specifications
Background
Antimicrobial protein that is an integral component of the innate immune system. Binds to bacterial lipopolysaccharides (LPS) . Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2. Postsecretory processing generates multiple cathelicidin antimicrobial peptides with various lengths which act as a topical antimicrobial defense in sweat on skin. The unprocessed precursor form, cathelicidin antimicrobial peptide, inhibits the growth of Gram-negative E.coli and E.aerogenes with efficiencies comparable to that of the mature peptide LL-37 (in vitro) .
Abbreviation
LL-37
Synonyms
18 kDa cationic antimicrobial protein; CAMP; CAMP_HUMAN; CAP-18; Cathelicidin antimicrobial peptide; FALL39; HSD26; hCAP-18
UniProt
P49913
Accession Number
P49913
Expression System
E.coli
Tag
N-GST
Sequence
Leu 134-Ser 170
Field of Research
Microbiology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
29.0 kDa
Observed Molecular Weight
32 kDa
Species
Human
Available Sizes
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