Recombinant Human ATXN2 protein (GST tag)
Product Specifications
Background
Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
Abbreviation
ATXN2
Synonyms
ATX2; ATXN2; Ataxin-2; SCA2; Spinocerebellar ataxia type 2 protein; TNRC13; Trinucleotide repeat-containing gene 13 protein
UniProt
Q99700
Accession Number
Q99700
Expression System
E.coli
Tag
N-GST
Sequence
Leu 460-Ser 600
Field of Research
Epigenetics and Nuclear Signaling
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
40.4 kDa
Observed Molecular Weight
42 kDa
Species
Human
Available Sizes
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