Recombinant Human THAP1 protein (His tag)
Product Specifications
Background
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Abbreviation
THAP1
Synonyms
THAP domain-containing protein 1
UniProt
Q9NVV9
Accession Number
Q9NVV9
Expression System
E.coli
Tag
N-His
Sequence
Met1-Phe81
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 80% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/ql4xpc
Product MSDS
https://789.bio/eb/qqHpq9
Calculated Molecular Weight
9.5 kDa
Observed Molecular Weight
11 kDa
Species
Human
Available Sizes
Curated Selection
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