Recombinant Human GSK3α Protein
Product Specifications
Background
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1.
Abbreviation
GSK3α
Synonyms
GSK-3 alpha; GSK3A; Glycogen synthase kinase-3 alpha; Serine/threonine-protein kinase GSK3A
UniProt
P49840
Accession Number
P49840
Expression System
E.coli
Tag
N-His
Sequence
Ser97-Pro448
Field of Research
Stem cells; Cardiovascular; Cell Biology; Neuroscience; Signal Transduction
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 80% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/0gdusk
Product MSDS
https://789.bio/eb/4OV5V9
Calculated Molecular Weight
39.4 kDa
Observed Molecular Weight
39 kDa
Species
Human
Available Sizes
Curated Selection
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