Recombinant Human CCL14 Protein
Product Specifications
Background
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1 (9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
Abbreviation
CCL14
Synonyms
C-C motif chemokine 14; CC-1; CC-3; HCC-1; HCC-1 (1-74) ; HCC-3; NCC-2; NCC2; SCYA14; Small-inducible cytokine A14
UniProt
Q16627
Accession Number
Q16627
Expression System
E.coli
Tag
N-His
Sequence
Thr20-Asn93
Field of Research
Immunology; Cardiovascular
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
8.7 kDa
Observed Molecular Weight
12 kDa
Species
Human
Available Sizes
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