Recombinant Human IL-1Ra Protein
Product Specifications
Background
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2, however, the physiological relevance of the latter association is unsure.
Abbreviation
IL-1Ra
Synonyms
IL1F; MVCD; IL1RN; DIRA; ICIL-1RA; IL-1RN; IL-1ra; IL-1ra3; IL1F3; IL1RA; IRAP; MVCD4; Anakinra; IL1 inhibitor; Interleukin-1 receptor antagonist protein; F630041P17Rik; ICIL 1RA; ICIL1RA; IL1RN (IL1F3) ; Interleukin 1 receptor antagonist; Intracellular IL 1 receptor antagonist type II; Intracellular interleukin 1 receptor antagonist (icIL 1ra) ; MGC10430; Type II interleukin 1 receptor antagonist
UniProt
P18510
Accession Number
P18510
Expression System
E.coli
Tag
N-His
Sequence
Arg26-Glu177
Field of Research
Cancer; Cardiovascular; Immunology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/9c4g0k
Product MSDS
https://789.bio/eb/1xa5RC
Calculated Molecular Weight
19.4 kDa
Observed Molecular Weight
19 kDa
Species
Human
Available Sizes
Curated Selection
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