Recombinant Human IL-1Ra Protein

Product Specifications

Background

Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2, however, the physiological relevance of the latter association is unsure.

Abbreviation

IL-1Ra

Synonyms

IL1F; MVCD; IL1RN; DIRA; ICIL-1RA; IL-1RN; IL-1ra; IL-1ra3; IL1F3; IL1RA; IRAP; MVCD4; Anakinra; IL1 inhibitor; Interleukin-1 receptor antagonist protein; F630041P17Rik; ICIL 1RA; ICIL1RA; IL1RN (IL1F3) ; Interleukin 1 receptor antagonist; Intracellular IL 1 receptor antagonist type II; Intracellular interleukin 1 receptor antagonist (icIL 1ra) ; MGC10430; Type II interleukin 1 receptor antagonist

UniProt

P18510

Accession Number

P18510

Expression System

E.coli

Tag

N-His

Sequence

Arg26-Glu177

Field of Research

Cancer; Cardiovascular; Immunology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.