Recombinant Human CD74 protein (His Tag)
Product Specifications
Background
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Abbreviation
CD74
Synonyms
CD 74; CD74 antigen (invariant polypeptide of major histocompatibility complex; CD74 molecule; CLIP; DHLAG; Gamma chain of class II antigens; HG2A; HLA class II histocompatibi; class II antigen-associated) ; class II invariant chain; major histocompatibility complex
UniProt
P04233
Accession Number
P04233
Expression System
E.coli
Tag
N-His
Sequence
Gln73-Met296
Applications
Immunogen
Field of Research
Immunology
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
26.6 kDa
Observed Molecular Weight
30-33 kDa
Species
Human
Available Sizes
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