Recombinant Human CD74 protein (His Tag)

Product Specifications

Background

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Abbreviation

CD74

Synonyms

CD 74; CD74 antigen (invariant polypeptide of major histocompatibility complex; CD74 molecule; CLIP; DHLAG; Gamma chain of class II antigens; HG2A; HLA class II histocompatibi; class II antigen-associated) ; class II invariant chain; major histocompatibility complex

UniProt

P04233

Accession Number

P04233

Expression System

E.coli

Tag

N-His

Sequence

Gln73-Met296

Applications

Immunogen

Field of Research

Immunology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.