Recombinant Human Merlin/NF2 protein (His Tag)
Product Specifications
Background
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Abbreviation
Merlin; NF2
Synonyms
BANF; Bilateral acoustic neuroma; CAN; MERL_HUMAN; Merlin; Moesin ezrin radixin like protein; Moesin ezrin radizin like; Moesin-ezrin-radixin-like; NF 2; Neurofibromatosis 2; Neurofibromatosis type 2; Neurofibromatosis2; SCH; Schwannomerlin
UniProt
P35240
Accession Number
P35240-1
Expression System
E.coli
Tag
N-His
Sequence
Met1-Leu595
Field of Research
Neuroscience, Signal Transduction, Epigenetics and Nuclear Signaling, Cancer
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
69.7 kDa
Observed Molecular Weight
68-71 kDa
Species
Human
Available Sizes
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