Recombinant Human PUMA/BBC3 protein (His Tag)
Product Specifications
Background
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis . Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.
Abbreviation
PUMA; BBC3
Synonyms
BBC 3; BBC3_HUMAN; BCL 2 binding component 3; BCL2 binding component 3; Bbc3; Bcl-2-binding component 3; JFY 1; JFY-1; JFY1; PUMA alpha; PUMA/JFY1; p53 Upregulated Modulator of Apoptosis; p53 up regulated modulator of apoptosis; p53 up-regulated modulator of apoptosis
UniProt
Q9BXH1
Accession Number
Q9BXH1-1
Expression System
E.coli
Tag
N-His
Sequence
Met1-Asn193
Applications
Immunogen
Field of Research
Cell Biology, Signal Transduction, Cancer, Metabolism
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
20.1 kDa
Observed Molecular Weight
20-24 kDa
Species
Human
Available Sizes
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