Recombinant Human KIT/SCFR Protein (His Tag)

Product Specifications

Background

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor) . Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

Abbreviation

KIT; SCFR

Synonyms

C Kit; CD117; KIT; KIT oncogene; KIT proto oncogene receptor tyrosine kinase; Kit; Kit Ligand; MGF; Mast cell growth factor receptor; Mast/stem cell growth factor receptor Kit; PBT; Piebald trait protein; Proto oncog; Proto oncogene c Kit; c-Kit; c-Kit Ligand; p145 c-kit

UniProt

P10721

Accession Number

P10721-1

Expression System

E.coli

Tag

N-His

Sequence

Gln26-Arg205

Field of Research

Immunology, Tags & Cell Markers, Signal Transduction, Neuroscience, Stem Cells, Cancer, Developmental Biology

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.