Recombinant Human HSPA1A Protein (His Tag)
Product Specifications
Background
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
Abbreviation
HSPA1A
Synonyms
HSP70-1B; HSP70-2; HSP70.2; heat shock protein family A (Hsp70) member 1A; heat shock protein family A (Hsp70) member 1B
UniProt
P0DMV8
Accession Number
P0DMV8-1
Expression System
E.coli
Tag
N-His
Sequence
Ala2-Asp641
Field of Research
Signal Transduction, Cancer
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 85% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
69.9 kDa
Observed Molecular Weight
72.2 kDa
Species
Human
Available Sizes
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