Recombinant Human FABP3 Protein (His Tag)
Product Specifications
Background
Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal-and cardiac-types. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. The FABP3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is also a candidate tumor suppressor gene for human breast cancer. FABP3 is a sensitive biomarker for myocardial infarction and can be detected in the blood within one to three hours of onset of pain.
Abbreviation
FABP3
Synonyms
FABP11; FABP3; Fatty Acid-Binding Protein 3; Fatty Acid-Binding Protein Heart; H-FABP; Heart-Type Fatty Acid-Binding Protein; M-FABP; MDGI; MDGIMuscle Fatty Acid-Binding Protein; Mammary-Derived Growth Inhibitor; O-FABP
UniProt
P05413
Accession Number
P05413
Expression System
E.coli
Tag
N-His
Sequence
Val2-Ala133
Field of Research
Cardiovascular; metabolism; Stem cells
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
17.0 kDa
Observed Molecular Weight
15 kDa
Species
Human
Available Sizes
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