Recombinant Human AIF1 Protein (His Tag)
Product Specifications
Background
Allograft Inflammatory Factor 1 (AIF1) contains two EF-hand domains and exists as a homodimer. AIF1 can be detected in T-lymphocytes and peripheral blood mononuclear cells. AIF1 functions as actin-binding protein that enhances membrane ruffling and RAC activation and can enhance the actin-bundling activity of LCP1. In addition, AIF1 plays a role in RAC signaling and in phagocytosis and may also in macrophage activation and function. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes and plays a role in vascular inflammation.
Abbreviation
AIF1
Synonyms
AIF-1; AIF1; Allograft Inflammatory Factor 1; G1; IBA1; Ionized Calcium-Binding Adapter Molecule 1; Protein G1
UniProt
P55008
Accession Number
P55008
Expression System
E.coli
Tag
C-His
Sequence
Ser2-Pro147
Field of Research
Cell biology; Neuroscience; immunology; metabolism
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
17.7 kDa
Observed Molecular Weight
16 kDa
Species
Human
Available Sizes
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