Recombinant Bovine TGFBR1 protein (His tag)

Product Specifications

Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta.

Abbreviation

TGFBR1

Synonyms

AAT5; ACVRLK 4; ALK 5; Activin A receptor type II like kinase 53kDa; Activin receptor like kinase 5; LDS1A; MSSE; SKR4; Serine/threonine-protein kinase receptor R4; TGF beta Receptor I; TGFR 1; TbetaR-I

UniProt

O46680

Accession Number

O46680

Expression System

E.coli

Tag

N-His

Sequence

Ile 143-Leu 330

Field of Research

Cardiovascular; Signal Transduction; Stem Cells; Cancer; Metabolism; Neuroscience

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.